Inhibition of Enzymatic Steroid 11β-Hydroxylation by Androgens
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چکیده
منابع مشابه
19-Hydroxylation of androgens in the rat brain.
Aromatization of androgens in the central nervous system is linked with sexual differentiation of the brain and, thus, determines the nature of sexual behavior and the control of gonadotropin secretion. The process of aromatization, as determined in the human placenta, proceeds through two successive hydroxylations at C-19, the products of which are then virtually completely converted via a thi...
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De Meio and Lewycka (1) have obtained indirect evidence that conjugation of dehydroisoandrosterone with sulfuric acid occurs in a system consisting of microsome-free supernatant fluid of rat liver, adenosine triphosphate (ATP), and magnesium and sulfate ions. They showed that, following incubation, some of the Zimmermann-positive material remains in the aqueous phase after ether extraction at p...
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In recent years the concept of the specificity of enzyme action has been subjected to revision. The proteolytic enzymes (1) have been shown to have esterase activity and the concept of a blood esterase as distinct from a blood lipase is no longer tenable (2). The enzymatic hydrolysis of the steroid hormone esters by blood sera (3) had not been suspected until solubility determinations of the es...
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The effect of proline analogs on peptidyl proline hydroxylation has been studied in vivo using aerated root slices of Daucus carota. One analog, 3,4-dehydroproline, acted at micromolar concentrations to rapidly and selectively inhibit peptidyl proline hydroxylation. A structurally altered hydroxyproline-rich cell wall glycoprotein was synthesized and secreted by dehydroproline-treated tissue. T...
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Sex steroids, also known as gonadal steroids, are oxidized with hydroxylation by cytochrome P450, glucuronidation by UDP-glucuronosyltransferase, sulfation by sulfotransferase, andO-methylation by catechol O-methyltransferase. Thus, it is important to determine the process by which inflammation influences metabolism of gonadal hormones. Therefore, we investigated the mechanism of metabolic enzy...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1963
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)81300-x